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Variations in genes that are important for the function of lysosomes — the cellular equivalent of garbage disposals, which are responsible for removing molecular waste from cells — may help set the stage for the development of Parkinson’s disease in people who’ve had long-term pesticide exposure, a new study…

Researchers have developed analogs of cannabinol (CBN), a lesser-known cannabinoid, that show neuroprotective abilities in lab studies not unlike the effects from the active chemicals in the cannabis plant, which are a benefit in Parkinson’s as well as other neurodegenerative diseases. “Not only does CBN have neuroprotective…

Researchers in Canada have developed a new method to generate functional dopaminergic neurons, the dopamine-producing nerve cells lost in Parkinson’s disease, from human pluripotent stem cells (hPSC). The scientists used an antibody to selectively activate FZD5, a receptor, in the stem cells, which stimulated a specific molecular signaling pathway involved…

Self-care is important for people with Parkinson’s disease, and patients should be armed with tools for tracking symptoms, keeping informed about the disease, and leaning on support from others. That’s according to a study, “Balancing feeling ‘prepared’ without feeling ‘devoured’: A qualitative study of self-care from…

Toxic substances that enter via the nose or gut give rise to toxic protein clumps that eventually cause Parkinson’s disease, researchers propose. “In both the brain-first and body-first scenarios the [disease mechanism] arises in structures in the body closely connected to the outside world,” Ray Dorsey, MD, a professor…

Parkinson’s disease may change the way basic emotions — such as anger, disgust, fear, happiness, sadness, and surprise — are felt in the body, a study suggests, opening up new perspectives into the disease’s nonmotor symptoms and how they’re managed. “The results of our study raise many interesting questions…

After adding $47 million in new funding, Cerevance is planning to launch a Phase 3 clinical trial to test its oral molecule CVN424, designed to treat people with early-stage Parkinson’s disease without the side effects seen with other therapies, the company announced in a press release. That…

There appears to be no link between a unique pattern of the gut microbiome — the genetic material carried by all of the microorganisms, such as bacteria, living in the gut — and mild cognitive impairment in people with Parkinson’s disease, a study found. The study, “Gut microbiome…

Scientists exploring the potential of machine learning approaches in drug discovery for Parkinson’s disease and other neurodegenerative disorders — focusing on misfolded proteins that are the hallmark of such conditions — found that one such method identified compounds “two orders of magnitude more potent” than ones previously reported, per…

People who carry a specific mutation in the RAB32 gene have a higher risk of developing Parkinson’s disease, researchers at the University of Florida found. The mutation, called RAB32 Ser71Arg, was identified in 16 individual families from different ethnic groups and increased the activation of the LRRK2 protein, a…